Program "Promis" PsyCise project

Acronym: PsyCise

Title: Utility of plasma drug level monitoring and CYP2C19/CYP2D6 genotyping in dose personalization of antidepressants and antipsychotics

Ukupan budžet: 199.872,88 EUR

With the cumulative global prevalence of 7%, affective disorders cause significant burden to the society world-wide. Moreover, the antidepressants and antipsychotics are not always effective and at the same time, the research on and development of the new psychotropic drugs is near standstill; in such a situation it is of paramount importance to maximize the effectivness of the medications that are currently available on the market. Escitalopram and sertraline are commonly prescribed antidepressants metabolized by the polymorphic CYP2C19 liver enzyme, while risperidone and aripiprazole are commonly prescribed antipsychotics metabolized by the polymorphic CYP2D6 liver enzyme. Therefore, depending on the CYP2C19/CYP2D6 genotype, the patients can be normal metabolizers (normal drug exposure), intermediate metabolizers (moderately increased exposure), and poor metabolizers (profoundly increased exposure). Inadequate exposure can lead to either insufficient effectiveness or adverse drug reactions and therefore it is very important to administer the correctly individualiye the dose. Proposed multicentric clinical study aims to (1) establish the personalized dosing guided by CYP2C19/CYP2D6 genotyping and plasma level quantification for escitalopram, sertraline, risperidone and aripiprazole in two major psychiatric hospitals and to (2) quantify how much can escitalopram-, sertraline-, risperidone-, or aripiprazole-treated patients benefit from such a science-based personalized dosing. Considering the burden of psychiatric disorders and frequency of suicide among psychiatric patients, improving the outcome the treatment with antipsychotics and antidepressants has a potential to significantly improve life quality of the population suffering from psychiatric disorder and to save lives of potential suicide victims..

Project leader

1. Marin Jukić PharmM PhD - University in Belgrade - Faculty of Pharmacy, Dept. of Physiology

Project participats - PROMIS grant applicants

1. Nađa Marić Bojović MD PhD – University in Belgrade - Faculty of Medicine, Dept. of Psychiatry & Institute for Mental Health
2. Zvezdana Stojanović MD PhD – University of Defence – Military Medical Academy, Dept. Of Psychiatry & Military Medical Academy – Psychiatry clinic
3. Bojan Marković PharmM PhD – University in Belgrade - Faculty of Pharmacy, Dept. Of Pharmaceutical chemistry
4. Bojan Batinić PharmM PhD – University in Belgrade - Faculty of Pharmacy, Dept. of Physiology

Filip Milosavljević PharmM (PhD student) – University in Belgrade - Faculty of Pharmacy

Project participants

1. Čedo Miljević MD PhD - Univerzitet u Beogradu - Faculty of Medicine, Dept. of Psychiatry & Institute for Mental Health
2. Zorana Pavlović MD PhD - University in Belgrade - Faculty of Medicine, Dept. of Psychiatry & Clinical Centre of Serbia – Psychiatry clinic
3. Danilo Joković - Military Medical Academy – Psychiatry clinic

Prof Svetlana Ignjatović PharmM PhD - University in Belgrade - Faculty of Pharmacy, Dept. of Medical Biochemistry

1. Vesna Pešić PharmM PhD - University in Belgrade - Faculty of Pharmacy, Dept. of Physiology

Sandra Vladimirov PharmM PhD - University in Belgrade - Faculty of Pharmacy, Dept. of Medical Biochemistry

Ivana Savić PharmM (PhD student) – University in Belgrade - Faculty of Pharmacy

Dušan Jovanović PharmM (PhD student) – University in Belgrade - Faculty of Pharmacy

Marija Repac PharmM (PhD student) – University in Belgrade - Faculty of Pharmacy

Bojana Krivokuća PharmM (PhD student) – University in Belgrade - Faculty of Pharmacy

Marina Manojlović (student) – University in Belgrade - Faculty of Pharmacy

Teodora Miloševski (student) – University in Belgrade - Faculty of Pharmacy

Nikola Ašujić (student) – University in Belgrade - Faculty of Pharmacy

Isidora Kosmajac (student) – University in Belgrade - Faculty of Pharmacy

Milica Tenić (student) – University in Belgrade - Faculty of Pharmacy

Aldin Selmani (student) – University in Belgrade - Faculty of Pharmacy

Andrea Atanasov (student) – University in Belgrade - Faculty of Pharmacy

Anđela Tošić (student) – University in Belgrade - Faculty of Pharmacy

Milan Tatarević - Clinical Centre of Serbia – Psychiatry clinic

Our vision is to utilize the advancement in molecular dianostics and health system capabilities to provide each psychiatric patients with the right medication at the right dose