Katarina Nikolić, PhD

Dr sc. Katarina Nikolić

Position: Associate Professor
Organizational unit: Department of Pharmaceutical Chemistry
Address: Vojvode Stepe 450, 11221 Belgrade, Serbia
Room: 207
Phone: +381 11 3951-259
Fax: +381 11 397-43-49
Email: knikolic@pharmacy.bg.ac.rs


CV


Dr. Katarina Nikolic was born on 04.02.1975. in Sremska Mitrovica, Serbia. She completed gymnasium in Ruma in 1993, and graduated at Faculty of Pharmacy University of Belgrade in 1998, with an average mark 9.23.

In 1999 she was awarded as the best student of generation at Faculty of Pharmacy for the academic 1997/98 year.

In 2001 she completed Master study at Faculty of Physical Chemistry, University of Belgrade and defended Master thesis: "Application of near infrared spectroscopy for the quantitative analysis of hydrocortisone sodium succinate for injection", mentor Professor Ubavka Mioč, Faculty of Physical Chemistry, University of Belgrade.

From 2001 to 2005 she participated as a Research Assistant on international project "Synthesis, anticancer and antioxidant activities of mixed selenium - tocopherol antioxidants", principal investigator Professor Anastasios Keramidas, Faculty of Chemistry, University of Nicosia, Cyprus.

In 2007 she defended PhD thesis: "Molecular modeling and in vitro antioxidant properties of phenilselenosuccinyl-α-tocopheryl esters with potential antiproliferative activities", mentor Professor Danica Agbaba, Department of Pharmaceutical Chemistry and Drug Analysis, Faculty of Pharmacy, University of Belgrade.

Since 2007 she has worked as an Assistant on Pharmaceutical Chemistry II and III courses at the Faculty of Pharmacy.

From year 2012 Dr. Katarina Nikolic was employed Assistant Professor at Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade.

Since 2017 Dr. Katarina Nikolic is employed as Associate Professor at Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade.

Since 2007 she participates at the research projects of the Ministry of Education, Science and Technological Development of the Republic of Serbia, principal investigator Professor Danica Agbaba, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade (142071, 172033). From year 2010 she is also involved in national research project of Institute of Nuclear Sciences - Vinča, University of Belgrade (173001).

Dr. Katarina Nikolic was involved in three FP7/COST (European Cooperation in Science and Technology) international project CM0603 (2008-2011), CM1103 (2011-2015) and CM1207 (2013-2017).

She is currently involved in three Horison 2020/COST projects: CA15135, CA16205, and CM1406 Epichembio http://epichembio.eu/

The main scientific research areas of Dr. Katarina Nikolic include: molecular modeling, QSAR, QSPR, QSRR, 3D-pharmacophore modeling, computer-aided drug design, virtual docking, virtual screening, molecular dynamic, lead optimisation, synthesis, in vitro/in silico ADMET screening, and application of chemometric methods for analytical methods development (HPLC, UPLC, HP-TLC, CE, LC-MS). Her research is focused on development of new antihypertensives, anticancer compounds and drugs for treatment of neurodegenerative diseases.

Dr. Katarina Nikolic has published seventy five manuscripts in international scientific journals and one international monography. She has held more than ten oral presentations at international conferences.

  • S. Filipic, K. Nikolic, I. Vovk, M. Krizman, D. Agbaba, Quantitative structure-mobility relationship analysis of imidazoline receptor ligands in CDs-mediated CE, Electrophoresis, 34, 471-482 (2013).
  • B. M. Ivkovic, K. Nikolic, B. B. Ilic, Z. S. Zizak, R. B. Novakovic, O. A. Cudina, S. M. Vladimirov, Phenylpropiophenone derivatives as potential anticancer agents: Synthesis, biological evaluation and quantitative structure activity relationship study, European Journal of Medicinal Chemistry, 63, 239-255 (2013).
  • O.M. Bautista-Aguilera, A. Samadi, M. Chioua, K. Nikolic, S. Filipic, D. Agbaba, E. Soriano, L. Andrés, M.I. Rodríguez-Franco, S. Alcaro, R.R. Ramsay, F. Ortuso, M. Yañez, J.M. Contelles. N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a New Cholinesterase and Monoamine Oxidase Dual Inhibitor. Journal of Medicinal Chemistry 57, 10455-10463 (2014).
  • K. Nikolic, L. Mavridis, O.M.B. Aguilera, J.M. Contelles, H. Stark, M. Carreiras, I. Rossi, P. Massarelli, D. Agbaba, R.R. Ramsay, J.B.O. Mitchell. Predicting targets of compounds against neurological diseases using cheminformatic methodology. Journal of Computer Aided Molecular Design 29, 183–198 (2015).
  • J. Vucicevic, K. Nikolic, V. Dobricic , D. Agbaba. Prediction of Blood – Brain Barrier Permeation of α-Adrenergic and Imidazoline Receptor Ligands using PAMPA technique and Quantitative-Structure Permeability Relationship analysis. European Journal of Pharmaceutical Sciences 68, 94-105 (2015).
  • S. Butini, K. Nikolic, S. Kassel, H. Brückmann, S. Filipic, D. Agbaba, S. Gemma, S. Brogi, M. Brindisi, G. Campiani, H. Stark. Polypharmacology of dopamine receptor ligands. Progress in Neurobiology 142, 68-103 (2016).
  • Z. Gagic, B. Ivkovic, T. Srdic-Rajic, J. Vucicevic, K. Nikolic, D. Agbaba. Synthesis of the vitamin E amino acid esters with an enhanced anticancer activity and in silico screening for new antineoplastic drugs. European Journal of Pharmaceutical Sciences 88, 59-69 (2016).
  • J. Vucicevic, T. Srdic-Rajic, M. Pieroni, J.M. Laurila, V. Perovic, S. Tassini, E. Azzali, G. Costantino, S. Glisic, D. Agbaba, M. Scheinin, K. Nikolic, M. Radi, N. Veljkovic. A combined ligand- and structure-based approach for the identification of rilmenidine-derived compounds which synergize the antitumor effects of doxorubicin. Bioorganic and Medicinal Chemistry 24, 3174-83 (2016).
  • S. Filipic, D. Ruzic, J. Vucicevic, K. Nikolic, D. Agbaba. Quantitative structure-retention relationship of selected imidazoline derivatives on α1-acid glycoprotein column. Journal of Pharmaceutical and Biomedical Anal. 127, 101-111, (2016).
  • L. Ismaili, B. Refouvelet, M. Benchekroun, S. Brogi, M. Brindisi, S. Gemma, G. Campiani, S. Filipic, D. Agbaba, G. Esteban, M. Unzeta, K. Nikolic, S. Butini, J.M. Contelles. Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer’s disease. Progress in Neurobiology 151, 4-34 (2017).